International Journal of Drug Discovery and Medical Research 2023-06-01T06:03:56-04:00 Open Journal Systems <p><span style="color: #333333; font-family: 'Open Sans', sans-serif; font-size: 13px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: justify; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-stroke-width: 0px; background-color: #ffffff; text-decoration-thickness: initial; text-decoration-style: initial; text-decoration-color: initial; display: inline !important; float: none;">International Journal of drug discovery and medical research (Int J drug discov medi research) <strong>ISSN 2278-4799 </strong> is an international peer review quarterly, scientific online Journal. This Journal publishes original research work that contributes significantly scientific knowledge in medical sciences, pharmaceutical sciences including all branch of subject like Pharmaceutical Technology, Pharmacology, clinical pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmaceutics Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics, Pharmaceutical Analysis, Pharmacognosy, Natural Product Research, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics, and Biotechnology etc..</span></p> BONE MARROW TREPINE BIOPSY: STILL AN IMPORTANT DIAGNOSTIC TOOL IN THE 21ST CENTURY 2023-06-01T04:44:30-04:00 Sofia M, Abdullahi BB <p>Trepine biopsy is an indispensable diagnostic tool in the 21st century, and despite its long origins, its value remains innovative <br>in developing countries. The outcome of a bone marrow biopsy report depends on many factors, including detailed patient <br>clinical information, cross-departmental affiliations, working knowledge, and the technical capabilities of staff. Molecular <br>studies of biopsies are needed to increase diagnostic accuracy and personalize treatment. We have reviewed articles on <br>trephine biopsy and its challenges to re-emphasize that trepine biopsy are an essential diagnostic tool in our time.<br><br></p> 2023-06-01T00:00:00-04:00 Copyright (c) 2023 PERIOPERATIVE PSYCHIATRIC DISORDERS 2023-06-01T05:04:21-04:00 Theofilidis Antonis <p><strong>Background:</strong> Surgery is a very stressful situation for humans, resulting in various psychiatric problems. Fear of the operation <br>process, fear of the unknown, death anxiety along with changes in primary personal, family and professional roles, cause the <br>manifestation of problems from the mental realm. The effects of psychiatric disorders can have a profound effect on both the <br>mental and physical health of the patient.<br><strong>Aim:</strong> The aim of this study is to present psychiatric disorders during the Perioperative period.<br><strong>Material and method:</strong> The method used to write this study is the literature review. The writing was done by studying books, <br>scientific articles and internet search.<br><strong>Results:</strong> Psychiatric problems such as anxiety, depression, delirium at their onset, affect the preoperative and postoperative <br>condition of the patient. <br><strong>Conclusions:</strong> The evaluation of psychiatric disorders experienced by patients should be an integral part of perioperative care. <br>Early diagnosis and early treatment are associated with the avoidance of chronicity and serious complications</p> 2023-06-01T00:00:00-04:00 Copyright (c) 2023 THE HEALTH SYSTEM IN SUDAN IS CHARACTERISED BY HEAVY RELIANCE ON CHARGING USERS AT THE POINT OF ACCESS 2023-06-01T05:14:36-04:00 Abdeen M. Omer <p style="text-align: justify;">The strategy of price liberalisation and privatisation had been implemented in Sudan over the last<br>decade, and has had a positive result on government deficit. The investment law approved recently has<br>good statements and rules on the above strategy in particular to pharmacy regulations. Under the<br>pressure of the new privatisation policy, the government introduced radical changes in the pharmacy<br>regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards<br>areas of need, reducing inequalities and promoting better health conditions. Medicines are financed<br>either through cost sharing or full private. The role of the private services is significant. A review of<br>reform of financing medicines in Sudan is given in this article. Also, it highlights the current drug supply<br>system in the public sector, which is currently responsibility of the Central Medical Supplies Public<br>Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative<br>studies about the impact of drug regulations on the quality of medicines and how to protect public health<br>against counterfeit or low quality medicines, although it is practically possible. However, the regulations<br>must be continually evaluated to ensure the public health is protected against by marketing high quality<br>medicines rather than commercial interests, and the drug companies are held accountable for their<br>conducts.</p> 2023-06-01T00:00:00-04:00 Copyright (c) 2023 SOCIAL SUPPORT AND PROMOTION OF THE WELLBEING IN WOMEN OF HALF AGE WITH CANCER OF NON-METASTATIC SUCKLE 2023-06-01T05:45:39-04:00 Saily Ramos Cuellar , Miguel Angel Toledo Mendez, Jesus Cuellar Alvarez <p>Objective: to propose a program of social support for the promotion of the well-being in women of half age with cancer of not <br>suckles metastatic residents in Santa Clara. The investigation embraced one period from January 2020 to January 2022 of the <br>Province Hospital “Celestino Hernandez Robau". Materials and methods: for sampling intentional non probabilistic composed <br>by 23 women of half age with cancer of suckles non metastatic. It gathers it of the data was carried out through the empiric <br>method the questionnaire and for the analysis of the data the statistical calculation was used. Results: it allowed the <br>introduction of improv ements in their design toward women of half age with cancer of suckles non metastatic. Conclusions: it <br>contributed to the establishment of a logical and coherent articulation among the specific objectives and the projects <br>psychosocial that compose the program.</p> 2023-06-01T00:00:00-04:00 Copyright (c) 2023 EXPLORATORY MODEL OF INTENTION TO VOTE IN THE COVID-19 ERA 2023-06-01T05:58:32-04:00 Javier Carreon Guillen, Cruz Garcia Lirios, Jorge Hernandez Valdes, Francisco Ruben Sandoval Vazquez, Miguel Bautista Miranda <p>Organizational lucidity and social responsibility corporate are two processes that explain the propensity of employees to <br>support their companies and politicians linked to it in an electoral contest, but when these voters perceive that rather the <br>government authorities limit the ecological initiatives of the companies, then their preferences, intentions and suffrages they <br>opt for alternative options to those of the government candidate in turn. Therefore, the objective of this paper has been to <br>establish the reliability and validity of an instrument that measures the expectations and intentions of voting in favor of <br>candidates that respect the environment to be able to contrast a model for the integral study of the phenomenon in different <br>contexts and samples. From a structural model It was observed that the expected risks and benefits directly predict and <br>indirectly through the expectations of consensus and dissent to the intention to vote in favor of a candidate of the current <br>administration, or to an alternative candidate. Research lines are recommended concerning the provisions of the voters with <br>respect to local environmental norms and values.</p> 2023-06-01T00:00:00-04:00 Copyright (c) 2023 COMMUNITY HEALTH ISSUES AND USE OF ALTERNATIVE CHEMICAL FORMULA RELATED AGENTS AS THERAPY 2023-06-01T06:03:56-04:00 Aneel Kapoor, Seema Shah Murad, Saima Masood, Shah Murad, Humaira Mahmood, Asia Firdous <p>The most widely recognized of the metabolic risk factors are atherogenic dyslipidemia, elevated blood pressure, and elevated <br>plasma glucose. Individuals with these characteristics commonly manifest a prothrombotic state and a pro -inflammatory state <br>as well. Atherogenic dyslipidemia consists of an aggregation of lipoprotein abnormalities including elev ated serum trigl yceri de <br>and apolipoprotein B (apoB), increased small LDL particles, and a reduced level of HDL cholesterol (HDL-C). The metabolic <br>syndrome is often referred to as if it were a discrete entity with a single cause. Available data suggest that it truly is a <br>syndrome, ie, a grouping of ASCVD risk factors, but one that probably has more than one cause. Regardless of cause, the <br>syndrome identifies individuals at an elevated risk for ASCVD. The magnitude of the increased risk can v ary according to <br>which components of the syndrome are present plus the other, non-metabolic syndrome risk factors in a particular person. <br>Design and Place of conduction: The research work was single blind placebo-controlled, conducted at Jinnah Hospital, Lahore <br>Research time: It was conducted from April 2021 to October 2021. Number of patients and their Age: Seventy five already <br>diagnosed primary and secondary hyperlipidemic patients were selected with age range from 17 to 65 years. Exclusion <br>criteria: Diabetes mellitus, cigarette smoking/alcohol addictive patients, peptic ulcer disease, hypothyroidism, kidney <br>dysfunction, any heart disease and liver disease. All patients were divided in three groups (group-I, group-II, group-III), 25 in <br>each group. Proforma for patients: Their baseline lipid profile data were taken and filed in specifically designed Performa, at <br>start of taking medicine. Patients group division: Twenty five patients of group-I were advised to take 10 grams of Flaxseeds in <br>three divided doses after meal. Twenty five patients of group-II were advised to take Ajwain seeds 10 grams in three divided <br>doses after each meal for two months. Twenty five patients of group-III were provided placebo capsul es, (containing grinded <br>rice), taking one capsule after each meal. All participants were advised to take these medicines for eight weeks. Follow-up<br>period: All participants were called fortnightly for their query and follow up. Their LDL-cholesterol and HDL-cholesterol was <br>determined at the hospital laboratory. Resul ts: In two months therapy by Flaxseeds decreased LDL-cholesterol from <br>195.11±2.11 mg/dl to 190.22±3.11 mg/dl, which is significant statistically. HDL was increased from 34.53±1.65 mg/dl to <br>38.97±2.29 mg/d, which is also significant change. In two months therapy by AJWAIN, LDL-c reduced from 201.51±2.62 mg/dl <br>to 197.11±2.66 mg/dl, which is significant statistically. HDL-cholesterol increased by Ajwain from 36.97±3.32 mg/dl to<br>37.45±1.87 mg/dl, which is insignificant statistically</p> 2023-06-01T00:00:00-04:00 Copyright (c) 2023