STUDIES ON INFLUENCE OF SELECTED HERBAL EXTRACTS ON PIOGLITAZONE ACTIVITY IN NORMAL RATS

Abstract

Diabetes, or type 2 diabetes, is a long-term metabolic disorder characterized by disturbances in the digestion of
carbohydrates, proteins, and lipids as well as problems controlling blood sugar levels. In order to assess the
safety and effectiveness of Momordica charantia, these plants were utilized both alone and in combination with
the standard antidiabetic medication Pioglitazone. The research was carried out on normal albino rats in order
to rapidly determine the impact of aqueous extracts of Momordica charantia on the pharmacodynamic activity
(specifically, blood glucose level) and Pioglitazone activity, with the intention of establishing the safety of their
combined clinical administration. Additionally, the study aimed to determine whether the drug interactions
observed in rats (rodents) were pharmacokinetic, pharmacodynamic, or both in nature. Blood samples may be
acquired by cutting a side ear vein many times in order to measure the levels of blood sugar, and the regular
medication. Pioglitazone, at dosages of 5, 10, and 20 mg/1.5 kg bd.wt, reduced the levels of glucose in the
blood in a dosage-dependent way. The observed increase in serum pioglitazone levels and pharmacokinetic
parameters suggest the presence of a pharmacokinetic interaction between AEMC and pioglitazone. Existing
diabetic medications are associated with certain limitations, such as inconsistent drug responses among
individuals, difficulty in maintaining glycemic control, and adverse side effects. Due to the fact that herbal
medicines are composed of natural substances, they may be erroneously perceived as innocuous.