CHARACTERIZATION AND SOLUBILITY STUDY OF THE DIABETES TYPE 2 DRUG REPAGLINIDE IN DIFFERENT SOLVENTS

Abstract

Repaglinide (RPGD) is prescribed for the treatment of type 2 diabetes mellitus. It has excellent therapeutic
potential due to its potency as a molecule; however, its variable bioavailability and low solubility in water
constitute a limitation. For the purpose of characterizing RPGD, the methodology employs a variety of
techniques, including melting point, solubility analysis in various solvents, UV spectrum, “Fourier transformed
infrared spectroscopy (FTIR)”, and “differential scanning calorimetric (DSC)” analysis. In results, the melting
point of RPGD was measured to be between 136 and 138 degrees Celsius. Tween 20, Oleic acid and methanol
has higher solubility of repaglinide. Nevertheless, the methodologies employed to improve the solubility of
RPGD could potentially be applied to other medications of a similar nature (BCS class-II). In conclusion, this
study utilized a formulation strategies-based approach to increase the substance's weakly soluble in water,
concentration RPGD.