NEUROPROTECTIVE EFFECTS OF TALINUM TRIANGULARE EXTRACT ON CEREBRAL INFARCTION AND OXIDATIVE STRESS IN A RAT MODEL OF ISCHEMIA-REPERFUSION INJURY

Abstract

ABSTRACT
Context: ischemia-related stroke is a primary cause of “mortality and disability,” which includes a disruption
in cerebral blood circulation and the ensuing damage to regeneration. Talinum triangular, a traditional
medicinal plant, has demonstrated various pharmacological properties, including antioxidative and
neuroprotective effects.
Method: Male rats (n=24) were divided into four groups: Sham Control, I/R Control, TTE 200 mg/kg, and TTE
400 mg/kg, with six rats in each group. Ischemia was induced by occluding the middle cerebellar stream for
ninety a few moments, then reperfusion for twenty-four hours. TTE was administered orally for seven days
prior to ischemia induction.
Results: TTE treatment significantly reduced cerebral infarction in a “dose-dependent manner,” with 19.74%
and 35.75% reduction at “200 mg/kg and 400 mg/kg, respectively, compared to the I/R control group”. TTE
also significantly increased SOD, catalase, and GSH levels while decreasing MDA levels, indicating enhanced
antioxidative defines and reduced oxidative stress. TTC staining corroborated these findings, showing less
neural damage in TTE-treated groups.
Conclusion: Talinum triangulate extract demonstrates substantial restorative benefits, from its antioxidant
activity qualities, against ischemia-reperfusion damage in rats. These results imply that TTE could be an
effective treatment for ischemia-related strokes, warranting further investigation into its mechanisms and
potential clinical applications.