AN OVERVIEW ON MICROSPONGE DELIVERY SYSTEM

Abstract

Microsponge were prepared by liquid-liquid suspension polymerization of styrene and methyl methacrylate. Microsponges were dispersed in gel prepared by using carbopol 940 and evaluated for drug release using Franz diffusion cell. Free flowing powder with size
distribution 30 to 107 µm was obtained. The average drug release from the gels containing microspongic fluconazole was 67.81% in 12 h. drug release from the
gels containing microsponge loaded fluconazole and marketed formulation has followed zero order kinetics. Microspongic system for topical delivery of fluconazole was observed potential in extending the release. A microsponge system for retinoic acid was developed
and tested for drug release and anti-acne efficiency.Statistically significant greater reductions in inflammatory and non-inflammatory lesions were obtained with entrapped tretinoin in the microsponge system. A new formulation of Hydroquinone (HQ) 4% with retinol 0.15% entrapped in microsponge reservoirs was developed to release HQ gradually to prolong exposure to treatment and to reduce skin irritation