DEVELOPMENT, CHARACTERIZATION & STABILIZATION OF POORLY WATER SOLUBLE DRUGS UTILIZING DISPERSION TECHNIQUES

Abstract

This article investigates enhancement of the dissolution profile of Telmisartan (TLM) is an angiotensin II receptor
antagonist which is used in the prevention and treatment of Hypertension. One of the major problems with it is its low
solubility in biological fluids, which results into poor bioavailability after oral administration (~42%) and late onset of
action, Using solid dispersion with β-CD & PEG-6000. The article also describes the preparation solid dispersions by using
Telmisartan β-CD & PEG -6000. A phase solubility method was used to evaluate phosphate buffer PH 7.4 & SLS 0.2%. solid
dispersions were prepared by the method of physical kneading solvent & Fusion method were performed for solid
dispersions of telmisartan at different molar ratios of 1:1, Infrared (IR) spectroscopy, The β-CD & PEG-6000 complexes
formulated by employing 1:1 (drug: complexing agent) with kneading technique showed higher drug release.