ANTI-INFLAMMATORY ACTIVITY OF COUMARIN AND STEROIDAL FRACTIONS FROM LEAVES OF MORINGA OLEIFERA

Authors

  • Prashant Kumar*1, S. Arora Yogesh Chand Yadav3 Sherwood College of Pharmacy, Barabanki, U.P. (India)

Keywords:

Moringa oleifera, Lysosomal Enzymes, Indomethacin.

Abstract

The extracts from leaves of Moringa oleifera Lam. were evaluated for Anti-inflammatory activity in rats with
formalin induced paw edema. A maximum inhibition (50.85%) of formalin induced paw edema was shown by
methanolic leaf extract. Steroidal fraction SF (18.64%) and coumarin fraction CF (44.06%) from leaves also
showed response showing to possess antiproliferative and antiarthritic activities similar to indomethacin, a
cyclooxygenase inhibitor. Against formalin induced increase in lysosomal enzymes, the methanolic leaf extract
(P<0.001), coumarin fraction CF M 1-4 and C 1-3 (P<0.001) and steroidal fraction SF (C 1-3) (P<0.01 to 0.001)
from methanolic leaf extract showed significant response. Thus the anti-inflammatory activities of extract and
some of the fractions may be because of the restabilization of lysosomal membrane. The coumarin fraction from
the leaves may thus be further explored for characterization and quantitative pharmacological correlation.

Author Biography

Prashant Kumar*1, S. Arora Yogesh Chand Yadav3, Sherwood College of Pharmacy, Barabanki, U.P. (India)

*1Sherwood College of Pharmacy, Barabanki, U.P. (India)
2Department of Pharmacy, Chitkara University, Chandigarh, Punjab (India)
3Department of pharmacy, Sumandeep Vidyapeeth Vadodara (G.J.) -391760, India

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Published

2022-04-10

Issue

Vol. 1 No. 1 (2012)

Section

Articles